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Plasma fluoride and enamel fluorosis
Calcified Tissue Research
|November 24, 1976
Summary
Temporary high fluoride (F) levels in blood plasma, not sustained high levels, are linked to enamel fluorosis. Peak plasma F concentrations around 10 muM are critical for blocking tooth enamel formation.
Area of Science:
- Biochemistry
- Toxicology
- Dental Research
Background:
- Fluoride (F) effects on bones and teeth are linked to tissue fluid concentrations, mirrored by blood plasma F.
- Plasma F levels are influenced by dietary F intake and skeletal F storage.
Purpose of the Study:
- To investigate the relationship between plasma F levels and enamel fluorosis in rats.
- To determine the critical plasma F concentrations associated with impaired enamel formation.
Main Methods:
- Determined fasting and post-ingestion/post-injection plasma F levels in rats.
- Utilized varying dietary F doses to induce different severities of enamel fluorosis.
Main Results:
- Temporary peak plasma F values, rather than elevated fasting levels, correlate with enamel fluorosis.
- Peak plasma F concentrations approaching 10 muM appear necessary to inhibit ameloblast function and block enamel formation.
Conclusions:
- Transient elevations in plasma fluoride are key determinants of enamel fluorosis.
- Plasma F level monitoring may have diagnostic and prognostic value for fluoride toxicity assessment.