[Sulpiride and psychic decompensation]

The use of sulpirid in psychiatry allows to delineate three types of activity of this compound which originality consists most in this triple association: neuroleptic activity, as well as anticonfusional and antidepressive. The psychodynamic and phenomenological evaluation of patients receiving a sulpirid treatment, has led us to consider the process of "psychic decompensation" as a target variable particularly sensitive to the action of this psychotropic drug. This process can be found in various pathological states--acute delirious states, depressive episodes, anxiety, autism, stress situation--where sulpirid acts, beside its specific thymoanaleptic or neuroleptic properties, through a "aspecific recompensation activity". This translates, psychopathologically, the action of sulpirid on the vegetative brain as well as the anti-stress properties of this psychrotropic drug, as verified in animal experiment.