Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methoxyflurane nephropathy.

R I Mazze

    Environmental Health Perspectives
    |June 1, 1976
    PubMed
    Summary

    The Fischer 344 rat serves as a valuable animal model for studying methoxyflurane nephrotoxicity. High dosage and fluoride levels are key factors, with other conditions potentially increasing kidney damage risk.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Composition of CO(2) absorbents.

    Anesthesia and analgesia·2001
    Same author

    Novel CO(2) absorbents and low-flow sevoflurane.

    Anesthesia and analgesia·2000
    Same author

    The effects of sevoflurane on serum creatinine and blood urea nitrogen concentrations: a retrospective, twenty-two-center, comparative evaluation of renal function in adult surgical patients.

    Anesthesia and analgesia·2000
    Same author

    Trace nitrous oxide levels in the postanesthesia care unit.

    Anesthesia and analgesia·1999
    Same author

    No evidence of sevoflurane-induced renal injury in volunteers.

    Anesthesia and analgesia·1998
    Same author

    Low-flow (1 l/min) sevoflurane: is it safe?

    Anesthesiology·1997

    Area of Science:

    • Toxicology
    • Pharmacology
    • Nephrology

    Background:

    • Methoxyflurane is an anesthetic agent with known nephrotoxic potential in humans.
    • Animal models are crucial for understanding drug-induced toxicity, requiring shared metabolic pathways and clinical manifestations.
    • The Fischer 344 rat has been identified as a suitable model for methoxyflurane nephrotoxicity studies.

    Purpose of the Study:

    • To evaluate the suitability of the Fischer 344 rat as an animal model for methoxyflurane-induced nephrotoxicity.
    • To identify the primary and secondary factors contributing to methoxyflurane nephrotoxicity in this model.

    Main Methods:

    • Utilized the Fischer 344 rat as an animal model for investigating methoxyflurane nephrotoxicity.
    • Analyzed the correlation between methoxyflurane dosage, serum inorganic fluoride concentration, and observed nephrotoxicity.
    • Considered various potential secondary contributing factors to the toxicological outcome.

    Main Results:

    • The Fischer 344 rat exhibits metabolic pathways and clinical signs relevant to human methoxyflurane nephrotoxicity.
    • High methoxyflurane dosage and elevated serum inorganic fluoride concentrations are identified as predominant factors.
    • Several secondary factors, including concurrent drug treatments and surgical procedures, may exacerbate kidney damage.

    Conclusions:

    • The Fischer 344 rat is a valuable and appropriate animal model for studying methoxyflurane nephrotoxicity.
    • Understanding the interplay of dosage, fluoride levels, and secondary factors is critical for mitigating methoxyflurane-induced kidney injury.
    • Further research can leverage this model to explore preventative and therapeutic strategies against anesthetic-related nephrotoxicity.

    Related Experiment Videos