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Perinatal nephropathies.

J E Gibson

    Environmental Health Perspectives
    |June 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Perinatal kidney development shows reduced function, making immature kidneys vulnerable to stress and chemical exposure. These insults can cause subtle or severe kidney abnormalities, impacting long-term health and adaptation.

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    Area of Science:

    • Developmental Biology
    • Nephrology
    • Toxicology

    Background:

    • Immature mammalian kidneys exhibit inherently lower functional capacity compared to adult kidneys.
    • Reduced glomerular filtration rate and limited tubular reabsorption characterize immature renal function, leading to nutrient loss.
    • The developing kidney's ability to cope with physiological stress is less robust than in mature kidneys.

    Purpose of the Study:

    • To review mammalian kidney development.
    • To evaluate the impact of perinatal manipulations on kidney development, both morphologically and functionally.
    • To understand how chemical exposures during the perinatal period affect renal development.

    Main Methods:

    • Literature review of mammalian kidney development.

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  • Analysis of studies on perinatal manipulations and their effects on renal morphology and function.
  • Examination of teratology experiments, particularly those involving chemical-induced renal anomalies.

    • Main Results:

    • Perinatal chemical exposures can induce varying degrees of altered kidney morphogenesis and function.
    • Hydronephrosis is a common observation in chemically induced renal anomalies.
    • Functional consequences of renal malformations range from inconsequential to lethal, potentially unmasked by stress.

    Conclusions:

    • Perinatal insults can lead to subtle or overt renal abnormalities with potential long-term functional consequences.
    • The adaptive capacity of the developing kidney under stress may be compromised by perinatal alterations.
    • Experimental testing is crucial for detecting and evaluating functional renal malformations that may not be apparent otherwise.