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Hyperprolactinemic male infertility.

S Segal, W Z Polishuk, M Ben-David

    Fertility and Sterility
    |December 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Elevated serum prolactin levels are common in infertile men, including those with oligospermia and azoospermia. Bromocriptine treatment effectively reduced prolactin and improved sperm count in one patient with hyperprolactinemic oligospermia.

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    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Urology

    Background:

    • Hyperprolactinemia, characterized by elevated serum prolactin levels, is a potential factor contributing to male infertility.
    • Understanding the prevalence and impact of hyperprolactinemia in different subgroups of infertile men is crucial for diagnosis and treatment.

    Purpose of the Study:

    • To investigate serum prolactin levels in fertile and infertile men, including those with oligospermia, azoospermia, and hypogonadotropic hypogonadism.
    • To assess the correlation between serum prolactin and other reproductive hormones (FSH, LH) and sperm parameters.
    • To evaluate the efficacy of bromocriptine in managing hyperprolactinemia and its effect on sperm production.

    Main Methods:

    • Serum prolactin levels were measured in 25 fertile men and 127 infertile men (91 oligospermic, 27 azoospermic, 9 hypogonadotropic hypogonadal).

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  • Hormonal assays for follicle-stimulating hormone (FSH) and luteinizing hormone (LH) were performed.
  • Sperm counts were analyzed.
  • Patients with hyperprolactinemia were treated with bromocriptine (2.5 mg twice daily).

    • Main Results:

    • Mean serum prolactin levels were significantly higher in all infertile groups compared to fertile men.
    • No significant correlation was found between serum prolactin and FSH, LH, or sperm count.
    • Hyperprolactinemia was identified in five infertile patients (2 oligospermic, 1 azoospermic, 2 hypogonadotropic hypogonadal).
    • Bromocriptine treatment successfully suppressed hyperprolactinemia in all affected patients.
    • One patient with hyperprolactinemic oligospermia showed a significant improvement in sperm count after bromocriptine therapy.

    Conclusions:

    • Elevated serum prolactin is prevalent in infertile men across various diagnoses.
    • While bromocriptine effectively manages hyperprolactinemia, its impact on improving sperm parameters may be specific to certain conditions like hyperprolactinemic oligospermia.