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Related Experiment Video

Updated: May 12, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
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Tropical enteropathy in Rhodesia.

G Thomas, D J Clain, A C Wicks

    Gut
    |November 1, 1976
    PubMed
    Summary

    Tropical enteropathy affects all in Rhodesia, but xylose absorption varies with socioeconomic status, not race. Lower infection exposure may explain better absorption in higher socioeconomic groups.

    Area of Science:

    • Gastroenterology
    • Tropical Medicine
    • Nutritional Science

    Background:

    • Tropical enteropathy is prevalent in developing countries, including Africa, potentially linked to tropical sprue.
    • Jejunal changes are observed across social and racial groups in Rhodesia.
    • Xylose excretion correlates with socioeconomic status, indicating malabsorption patterns.

    Purpose of the Study:

    • To investigate the characteristics of tropical enteropathy in Rhodesia.
    • To explore the relationship between socioeconomic status, race, and malabsorption.
    • To compare Rhodesian enteropathy with that found in other tropical regions.

    Main Methods:

    • Assessing jejunal changes.
    • Measuring xylose excretion.

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  • Evaluating Vitamin B12 and fat absorption.

    • Main Results:

    • Jejunal enteropathy is widespread, but xylose excretion is lower in lower socioeconomic Africans.
    • Higher socioeconomic Africans and Europeans show significantly greater xylose excretion.
    • Vitamin B12 and fat absorption remain normal, suggesting proximal small intestine involvement.

    Conclusions:

    • Socioeconomic status, not race, influences xylose absorption in Rhodesian tropical enteropathy.
    • Reduced exposure to gastrointestinal infections in higher socioeconomic groups may improve xylose absorption.
    • Milder enteropathy in Africa might be due to a lower incidence of acute gastroenteritis compared to other tropical areas.