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[Photosensitivity induced by piroxicam].

P Varela1, I Amorim, M Sanches

  • 1Serviço de Dermatologia, Hospital Geral de Santo António, Porto.

Acta Medica Portuguesa
|February 18, 1999
PubMed
Summary

Piroxicam, a common NSAID in Portugal, often causes photosensitivity reactions. Due to high thimerosal sensitization rates, which indicate piroxicam sensitivity, this drug should be avoided.

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Area of Science:

  • Dermatology
  • Pharmacology

Context:

  • Piroxicam is a widely prescribed non-steroidal anti-inflammatory drug (NSAID) in Portugal.
  • Photosensitivity skin reactions are a known adverse effect associated with piroxicam use.

Purpose:

  • To review the physiopathology and clinical presentation of piroxicam-induced photosensitivity.
  • To highlight the significance of thimerosal sensitization as a marker for piroxicam photosensitivity in Portugal.

Summary:

  • This review details the mechanisms and clinical manifestations of photosensitivity reactions to piroxicam.
  • A high prevalence of thimerosal sensitization in Portugal is identified as a marker for piroxicam photosensitivity.
  • The study suggests avoiding piroxicam due to its association with photosensitivity.

Impact:

  • Recommends alternative NSAIDs without significant photosensitivity risks.
  • Aims to reduce the incidence of adverse drug reactions in patients prescribed NSAIDs.
  • Informs dermatologists and prescribers about the risks associated with piroxicam in the Portuguese population.

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