Related Experiment Videos
Substituted 7H-pyrido[4,3-c]carbazoles with potent anti-HIV activity
1Faculty of Pharmacy, Meijo University, Nagoya, Japan.
Bioorganic & Medicinal Chemistry Letters
|February 18, 1999
Abstract:
Several substituted 7H-pyrido[4,3-c]carbazoles were synthesized from the natural product mukonal and tested for inhibition of HIV replication in H9 lymphocytes. 5-Methoxy-7-methyl-7H-pyrido[4,3-c]carbazole (7) had an EC50 value of 0.0054 microgram/mL and the highest therapeutic index (TI = 503) in the series.