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Isoxazoline GPIIb/IIIa antagonists bearing a phosphoramidate
J Wityak1, A E Tobin, S A Mousa
1DuPont Pharmaceuticals Company, Wilmington, Delaware 19880-0500, USA.
Bioorganic & Medicinal Chemistry Letters
|February 18, 1999
Abstract:
Isoxazolinylacetamides bearing a phosphoramidate group alpha- to the carboxylate moiety (3) were prepared and evaluated for in vitro antiplatelet efficacy. They were found to bind GPIIb/IIIa with high affinity and were potent antagonists of ADP mediated platelet aggregation.