Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The CD95(APO-1/Fas)/CD95L system.

P H Krammer1

  • 1Tumorimmunology Program, German Cancer Research Center, Heidelberg. p.krammer@dkfz-heidelberg.de

Toxicology Letters
|February 18, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain.

Cell death and differentiation·2015
Same author

AF-1 a novel regulator of the redox equilibrium during aging.

Free radical biology & medicine·2015
Same author

Induction of apoptosis by IFNγ in human neuroblastoma cell lines through the CD95/CD95L autocrine circuit.

Cell death and differentiation·2015
Same author

Tax contributes apoptosis resistance to HTLV-1-infected T cells via suppression of Bid and Bim expression.

Cell death & disease·2014
Same author

The traditional Chinese medical compound Rocaglamide protects nonmalignant primary cells from DNA damage-induced toxicity by inhibition of p53 expression.

Cell death & disease·2014
Same author

TNF-α mediates mitochondrial uncoupling and enhances ROS-dependent cell migration via NF-κB activation in liver cells.

FEBS letters·2013
Same journal

LEF1 regulated CTHRC1 Promotes Silica-Induced Pulmonary Fibrosis through CD44-Dependent Signaling.

Toxicology letters·2026
Same journal

hERG channel blockade and additive interactions of magnolol and honokiol from Magnolia species.

Toxicology letters·2026
Same journal

Evaluation of dose-dependent hematotoxic effects of celastrol on human blood cells in vitro.

Toxicology letters·2026
Same journal

Environmental pharmaceutical and antibiotic mixtures: An exposomics-guided framework for mechanistic toxicology.

Toxicology letters·2026
Same journal

Size- and morphology-dependent cytotoxicity of metal-organic frameworks: Deciphering the structure-toxicity relationship.

Toxicology letters·2026
Same journal

Steroidogenesis suppression in H295R cells by 1,3-disubstituted ureas: A potential off-target effect of some sEH inhibitors.

Toxicology letters·2026
See all related articles

Genetic defects in the CD95 system are discussed, alongside new findings on its signaling pathway. This system is crucial for immune function, particularly T-cell deletion and liver homeostasis.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • The CD95 system, a well-characterized death receptor pathway, is vital for immune regulation.
  • It plays critical roles in peripheral T-cell deletion and maintaining liver homeostasis.

Purpose of the Study:

  • To review genetic defects associated with the CD95 system.
  • To present recent advancements in understanding the CD95 signaling pathway.

Main Methods:

  • Literature review of genetic defects.
  • Analysis of recent findings on CD95 signaling.

Main Results:

  • Discussion of various genetic defects impacting CD95 function.
  • Elucidation of novel aspects of CD95-mediated signaling.

Related Experiment Videos

Conclusions:

  • Genetic defects in the CD95 system can lead to immune dysregulation.
  • Ongoing research continues to reveal the complexity of CD95 signaling in health and disease.