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Updated: Aug 15, 2026

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
Published on: March 28, 2017
Functional consequences of polymorphism of xenobiotic metabolising enzymes
1Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden. maging@ki.se
Abstract:
There are important interindividual differences in the rate of drug metabolism caused by genetic, environmental, pathological and dietary factors. The genetic variability caused by polymorphism encompasses a large proportion of phase I and phase II enzymes and results in either defect, ultrarapid, partially deficient or qualitatively altered drug metabolism. In this overview the most important polymorphic enzymes are discussed and their consequences for drug metabolism, effective drug treatment and adverse effects of drugs are emphasised.
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