Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum cytokines in thyrotoxicosis.

A Siddiqi1, J P Monson, D F Wood

  • 1Department of Clinical Biochemistry, St. Bartholomew's and Royal London School of Medicine and Dentistry, United Kingdom. a.siddiqi@mds.qmw.ac.uk

The Journal of Clinical Endocrinology and Metabolism
|February 18, 1999
PubMed
Summary

Thyroid hormone excess increases bone resorption by raising interleukin-6 and -8 levels, independent of autoimmune inflammation. Treatment normalizes these cytokine levels, suggesting thyroid hormones directly impact bone metabolism.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Peripheral Neuropathy After Chronic Alcohol Exposure in Mice: Impact of sex, total intake and duration and alcohol metabolism.

bioRxiv : the preprint server for biology·2025
Same author

The impact of COVID-19 on the mental health of dental students at an Australian school.

Australian dental journal·2024
Same author

Parental and training coaches' knowledge and attitude towards dental trauma management of children.

Australian dental journal·2022
Same author

Pedagogical development in local anaesthetic training in paediatric dentistry using virtual reality simulator.

European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry·2021
Same author

Diabetic patients' knowledge of the bidirectional link: are dental health care professionals effectively conveying the message?

Australian dental journal·2019
Same author

Salubrinal enhances eIF2α phosphorylation and improves fertility in a mouse model of Classic Galactosemia.

Biochimica et biophysica acta. Molecular basis of disease·2019

Area of Science:

  • Endocrinology
  • Bone Biology
  • Immunology

Background:

  • Thyroid hormone overproduction is linked to increased bone resorption.
  • Elevated serum interleukin-6 (IL-6) observed in thyrotoxicosis, but its cause (hormone excess vs. inflammation) is unclear.
  • Graves' disease (GD) and toxic nodular goiter (TNG) involve thyroid hormone excess and potential autoimmune inflammation.

Purpose of the Study:

  • To investigate whether osteotropic cytokines, specifically IL-6 and IL-8, mediate bone resorption in hyperthyroidism.
  • To differentiate the effects of thyroid hormone excess from autoimmune inflammation on cytokine levels.
  • To assess changes in IL-6 and IL-8 following treatment for hyperthyroidism.

Main Methods:

  • Longitudinal study of 34 hyperthyroid patients (GD, TNG, thyroid carcinoma on TSH suppression) and 12 controls.

Related Experiment Videos

  • Measurements included serum free T4, T3, IL-6, IL-8, IL-1beta, TNF-alpha, IL-11, bone-specific alkaline phosphatase (b-ALP), and urinary deoxypyridinoline (Udpd).
  • Measurements taken at baseline and for 6 months after carbimazole treatment.

    • Main Results:

    • Untreated GD and TNG patients showed significantly elevated IL-6 and IL-8 compared to controls.
    • These cytokine levels decreased to control levels after treatment.
    • Thyroid carcinoma patients on TSH suppressive therapy also had elevated IL-6 and IL-8.
    • IL-6 and IL-8 levels correlated with serum T3 and free T4, but not with bone resorption markers (Udpd, b-ALP).
    • IL-1beta, IL-11, and TNF-alpha were not elevated.

    Conclusions:

    • Elevated IL-6 and IL-8 in hyperthyroidism are primarily due to thyroid hormone excess, not autoimmune inflammation.
    • These cytokines likely originate from bone osteoblasts, despite lack of correlation with acute bone turnover markers.
    • Thyroid hormone excess directly influences cytokine production, contributing to bone resorption.