Modulation of the piriform cortex activity by the basal forebrain: an optical recording study in the rat

The piriform cortex (PCx) is the main projection area of the olfactory bulb. It further receives afferents from neurons located in the horizontal limb of the diagonal band (HDB) and the magnocellular preoptic nucleus (MCPO) of the basal forebrain. Using an optical recording technique, we examined the influence of electrical stimulation of the HDB-MCPO complex upon the PCx reactivity to electrical stimulation of the olfactory bulb. We observed an inhibitory modulation which was stronger on the intrinsic activity than on the afferent one. This effect was not homogeneously distributed within the whole PCx. The neurotransmitter involved and its synaptic target remain to be determined. The present findings are discussed in view of anatomical and functional data.