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Updated: Mar 18, 2026
An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
Sequence analysis and expression of a mouse homolog of human IkappaBL gene
M E Handel-Fernandez1, V Vincek
1Department of Microbiology and Immunology, University of Miami School of Medicine, P.O. Box 016960 (R-138), Miami, FL 33136, USA.
Abstract:
The family of transcriptional inhibitors, IkappaBLs, are critical to the regulation of cytokine and chemokine production. We have identified the complete cDNA sequence of the mouse IkappabL gene. The predicted 381-amino-acid sequence showed evidence of two ankyrin repeats characteristic of Ikappab family proteins and 92% identity to the IkappaBL human homolog. Although human IkappaBL has been reported to be ubiquitously expressed, here we show that mouse IkappaBL is transcribed in a more tissue-specific manner.
