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Related Experiment Videos

Interference of bencyclan with 11-hydroxycorticosteroids determinations.

J P Radó

    International Journal of Clinical Pharmacology and Biopharmacy
    |October 1, 1976
    PubMed
    Summary

    Bencyclan administration can cause falsely high readings in 11-hydroxycorticosteroids (cortisol) tests for hypertensive patients. These inaccurate results mean that 11-hydroxycorticosteroids assays are unreliable in patients taking bencyclan.

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    Area of Science:

    • Clinical Chemistry
    • Pharmacology
    • Endocrinology

    Background:

    • Accurate measurement of 11-hydroxycorticosteroids (cortisol) is crucial for diagnosing and managing various endocrine and metabolic conditions.
    • Hypertension is a common comorbidity associated with endocrine disorders.
    • Bencyclan is a medication with potential interactions that require investigation.

    Purpose of the Study:

    • To investigate the impact of bencyclan administration on the accuracy of plasma and urine 11-hydroxycorticosteroids assays.
    • To determine if bencyclan interferes with fluorimetric methods commonly used for cortisol measurement.

    Main Methods:

    • Analysis of plasma and urine samples from hypertensive patients undergoing bencyclan treatment.
    • Utilizing fluorimetric assays for the quantification of 11-hydroxycorticosteroids (cortisol).

    Main Results:

    • Falsely elevated fluorimetric readings for 11-hydroxycorticosteroids were observed in both plasma and urine samples.
    • The presence of bencyclan was associated with significant interference in the assay methodology.

    Conclusions:

    • Bencyclan administration leads to unreliable and falsely high results in 11-hydroxycorticosteroids (cortisol) assays.
    • Clinical conclusions drawn from 11-hydroxycorticosteroids measurements are invalid in patients treated with bencyclan.
    • Further studies are needed to understand the mechanism of interference and develop alternative assay methods.

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