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Laminin receptor in lymph node negative breast carcinoma
1Department of Pathology, University of Miami, Jackson Memorial Medical Center, Florida 33101, USA.
Cancer
|February 19, 1999
Summary
Expression of 67 kD laminin binding protein (67LR) in breast cancer is linked to less aggressive tumors. This finding suggests 67LR may indicate a better prognosis in node-negative patients.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Research
Background:
- 67 kD laminin binding protein (67LR) expression is linked to malignancy invasiveness.
- The role of 67LR in breast cancer has been unclear.
- This study investigates 67LR significance in 148 node-negative breast cancer patients.
Purpose of the Study:
- To explore the biologic significance of 67LR expression in breast carcinoma.
- To correlate 67LR expression with tumor characteristics and patient survival.
Main Methods:
- Immunohistochemistry using monoclonal antibody MLuC5 to detect 67LR.
- Correlation of 67LR staining with histologic and nuclear grade, estrogen receptor, and p53 status.
- Analysis of disease-free and overall survival in relation to 67LR expression.
Main Results:
- 67LR positivity correlated with lower histologic and nuclear grades (P=0.003, P=0.002).
- 67LR expression was associated with estrogen receptor positivity (P=0.003) and lack of p53 abnormality (P<0.001).
- 67LR did not independently affect survival, but ER positivity in 67LR+ patients predicted longer overall survival (P=0.008).
Conclusions:
- Tissue expression of 67LR is associated with better-differentiated, less aggressive breast carcinoma.
- 67LR may serve as a biomarker for less aggressive disease in node-negative breast cancer.
- Further research into 67LR's role in breast cancer progression is warranted.