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Molecular pathogenesis of chronic lymphocytic leukemia: factors and signaling pathways regulating cell growth and
G Meinhardt1, C M Wendtner, M Hallek
1Medizinische Klinik, Klinikum Innenstadt, Ludwig-Maximilians-Universität, Munich, Germany.
Journal of Molecular Medicine (Berlin, Germany)
|February 19, 1999
Abstract:
Chronic lymphocytic leukemia is a malignant disease characterized by clonal expansion of relatively mature B-lymphocytes with a high percentage of cells arrested in the nonproliferative G0/G1 cell cycle phase. Possibly reflecting the clinical heterogeneity observed in patients, various signaling pathways may become affected during the initiation and course of this disease. This review discusses frequent alterations concerning proliferative, differentiation-inducing, and apoptotic pathways elucidated in the recent years that have improved our understanding of this disease.