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Multimodal approach in invasive fetal therapy
G Noia1, D Romano, M De Santis
1Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, Rome, Italy.
Acta Obstetricia Et Gynecologica Scandinavica
|February 19, 1999
Summary
Integrated fetal therapy using multiple invasive procedures improves survival for nonimmune fetal hydrops and limits kidney damage in urinary tract malformations before birth.
Area of Science:
- Perinatology
- Maternal-Fetal Medicine
- Fetal Surgery
Background:
- Integrated fetal therapy combines complementary invasive procedures for comprehensive prenatal diagnosis.
- This approach aims to maximize information gathering on fetal compartments.
Purpose of the Study:
- To assess the diagnostic and therapeutic utility of complementary invasive procedures.
- Focus on fetuses with nonimmune fetal hydrops (NIFH) and urinary tract malformations (UTMs).
Main Methods:
- A study involving 50 fetuses from singleton pregnancies.
- Each fetus underwent at least three invasive procedures for diagnostic and therapeutic purposes.
- Procedures were categorized into two groups based on study periods: 1988-1992 and 1993-1995.
Main Results:
- Integrated invasive procedures significantly impacted fetal-neonatal survival rates in NIFH cases.
- For UTMS requiring postnatal surgery, these procedures limited intrauterine renal damage.
Conclusions:
- Complementary invasive procedures are particularly influential for fetal-neonatal survival in NIFH.
- In UTMS, these procedures mitigate intrauterine renal damage and can reduce the cesarean section rate.