Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leukotriene-receptor antagonists.

B J Lipworth1

  • 1Department of Clinical Pharmacology & Therapeutics, Ninewells Hospital and Medical School, University of Dundee, UK. b.j.lipworth@dundee.uk

Lancet (London, England)
|February 19, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Blood eosinophils: The forgotten man of inhaled steroid dose titration.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2017
Same author

Cardiopulmonary interactions with beta-blockers and inhaled therapy in COPD.

QJM : monthly journal of the Association of Physicians·2017
Same author

Bronchoprotective tolerance with indacaterol is not modified by concomitant tiotropium in persistent asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2017
Same author

Effects of the inverse alpha-agonist doxazosin in allergic rhinitis.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2016
Same author

From mouse to man: predicting biased effects of beta-blockers in asthma.

British journal of pharmacology·2015
Same author

Inhaled treatment for chronic obstructive pulmonary disease: what's new and how does it fit?

QJM : monthly journal of the Association of Physicians·2015
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
Same journal

Dual mobility total hip replacement in fractures: stability promotes patient confidence.

Lancet (London, England)·2026
Same journal

Dual mobility versus standard cups in total hip replacement for displaced femoral neck fractures (Duality): an international, multicentre, randomised, controlled, superiority trial.

Lancet (London, England)·2026
See all related articles

Leukotriene-receptor antagonists offer a novel, convenient oral treatment for asthma, acting as both anti-inflammatory and bronchodilator agents. These drugs also show promise for managing allergic rhinitis, frequently co-occurring with asthma.

Area of Science:

  • Pharmacology
  • Respiratory Medicine
  • Drug Development

Background:

  • Leukotriene-receptor antagonists represent a new class of antiasthma medications.
  • These drugs offer a unique combination of anti-inflammatory and bronchodilator properties.
  • Convenient oral administration (once or twice daily) is a key feature.

Purpose of the Study:

  • To overview the clinical pharmacology of leukotriene antagonists.
  • To appraise published clinical trial data on their efficacy.
  • To determine the role of these agents in current asthma management guidelines.

Main Methods:

  • Review of published clinical trial data.
  • Analysis of pharmacological profiles.
  • Evaluation of efficacy in various asthma severities.

Related Experiment Videos

Main Results:

  • Leukotriene-receptor antagonists demonstrate significant antiasthmatic activity.
  • Efficacy is observed in monotherapy and in combination with inhaled steroids.
  • Potential effectiveness in treating allergic rhinitis, often comorbid with asthma.

Conclusions:

  • Leukotriene-receptor antagonists are effective antiasthma drugs with a favorable profile.
  • Their utility extends to managing coexisting allergic rhinitis.
  • These agents warrant consideration within asthma management strategies.