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Progesterone alters biliary flow dynamics.

S Tierney1, A Nakeeb, O Wong

  • 1Department of Surgery, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA.

Annals of Surgery
|February 19, 1999
PubMed
Summary
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Progesterone impairs gallbladder function, reducing bile partitioning and emptying. This hormonal effect may explain the higher prevalence of gallstones and biliary motility disorders in women.

Area of Science:

  • Gastroenterology
  • Endocrinology
  • Biliary Physiology

Background:

  • Progesterone's role in biliary tract issues, including gallstones, is suggested but not fully understood.
  • Prolonged progesterone elevation (pregnancy, contraceptives) effects on biliary dynamics require further investigation.

Purpose of the Study:

  • To investigate the impact of progesterone on sphincter of Oddi and gallbladder function.
  • To determine progesterone's effect on bile flow dynamics.

Main Methods:

  • Adult female prairie dogs received subcutaneous progesterone implants or placebo.
  • Hepatic bile partitioning and gallbladder emptying were assessed using 99mTc-Mebrofenin cholescintigraphy.

Main Results:

Related Experiment Videos

  • Progesterone significantly reduced hepatic bile partitioning into the gallbladder.
  • Gallbladder ejection fraction decreased from 73% to 59% in progesterone-treated animals.
  • Gallbladder emptying rate was significantly reduced with progesterone administration.

    • Conclusions:

    • Progesterone alters hepatic bile partitioning and impairs gallbladder emptying.
    • These progesterone-induced changes in biliary motility may contribute to gallstone formation and motility disorders in women.