Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Positive sharp wave and fibrillation potential modeling.

D Dumitru1, J C King, W E Rogers

  • 1Department of Rehabilitation Medicine, University of Texas Health Science Center at San Antonio, 78284-7798, USA.

Muscle & Nerve
|February 19, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The addition of the MEP amplitude of finger extension muscles to clinical predictors of hand function after stroke: A prospective cohort study.

Restorative neurology and neuroscience·2019
Same author

Modeling Trans-Spinal Direct Current Stimulation in the Presence of Spinal Implants.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society·2019
Same author

Repeatability and reliability of muscle relaxation properties induced by motor cortical stimulation.

Journal of applied physiology (Bethesda, Md. : 1985)·2018
Same author

Modeling trans-spinal direct current stimulation for the modulation of the lumbar spinal motor pathways.

Journal of neural engineering·2017
Same author

Subsartorial Entrapment of the Saphenous Nerve of a Competitive.

The Physician and sportsmedicine·2016
Same author

Generalization and transfer of contextual cues in motor learning.

Journal of neurophysiology·2015
Same journal

Join AANEM.

Muscle & nerve·2026
Same journal

Targeted Muscle Reinnervation for Management and Prevention of Symptomatic Neuroma.

Muscle & nerve·2026
Same journal

AANEM News & Insights.

Muscle & nerve·2026
Same journal

Fat-Fraction Quantification Using Three-Point Dixon Technique in Duchenne Muscular Dystrophy and Its Correlation With Clinical Progression and Genotypic Characteristics: A Single Centre One-Year Prospective Study.

Muscle & nerve·2026
Same journal

Characterizing Combined Central and Peripheral Demyelination-Insights From a Multimodal Comparison With Chronic Inflammatory Demyelinating Polyneuropathy and Multiple Sclerosis.

Muscle & nerve·2026
Same journal

Electrical Modalities in the Rehabilitation of Peripheral Nerve Injuries: State of the Literature and Current Clinical Applications.

Muscle & nerve·2026
See all related articles

Computer simulations modeled muscle fiber potentials, revealing that a crush end, not a cut end, is necessary to detect fibrillation potentials and positive sharp waves extracellularly. This finding aids in understanding muscle electrical activity.

Area of Science:

  • Biophysics
  • Computational Neuroscience
  • Muscle Physiology

Background:

  • Understanding extracellular potentials from muscle fibers is crucial for diagnosing neuromuscular disorders.
  • Previous models often simplified muscle fiber terminations, potentially limiting accuracy.

Purpose of the Study:

  • To model extracellular potentials, specifically fibrillation potentials and positive sharp waves, using a finite muscle fiber simulation.
  • To investigate the impact of different muscle fiber end effects (cut vs. crush) on recorded potentials.

Main Methods:

  • Utilized a finite muscle fiber simulation program based on core conductor model assumptions.
  • Modeled two distinct end effects: a 'cut end' (termination of ion channels) and a 'crush end' (propagation block with maintained transmembrane potential).

Related Experiment Videos

  • Simulated intracellular action potentials (IAP) characteristic of denervated rat muscle.

    • Main Results:

    • A prototypical positive sharp wave was successfully modeled.
    • Extracellular detection of this wave required an IAP configuration from denervated muscle.
    • The specific 'crush end' model was essential for detecting the positive sharp wave, whereas a 'cut end' was insufficient.

    Conclusions:

    • The simulation highlights the critical role of specific muscle fiber termination types in generating detectable extracellular potentials.
    • The 'crush end' model accurately replicates conditions necessary for observing positive sharp waves, aiding in the interpretation of electrophysiological signals.
    • This computational approach provides insights into the biophysical mechanisms underlying abnormal muscle electrical activity.