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Absence of transcallosal inhibition in adolescents with diplegic cerebral palsy
F Heinen1, J Kirschner, U Fietzek
1Department of Neuropediatrics, Albert-Ludwigs-Universität Freiburg, Germany.
Muscle & Nerve
|February 19, 1999
Abstract:
The role of intracortical organization in the pathophysiology of cerebral palsy (CP) is not clear. We used transcranial magnetic stimulation to investigate the paradigm of transcallosal inhibition (TI) in a group of adolescent patients with diplegic CP (n = 4), hereditary spastic paraplegia (n = 2), and healthy control adolescents (n = 4). None of the patients with CP showed TI, whereas all other subjects had normal TI. These findings indicate a lack of inhibitory control of the motor cortex in CP.