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Serum triglyceride: a possible risk factor for ruptured abdominal aortic aneurysm
1BUPA Epidemiology Research Group, Wolfson Institute of Preventive Medicine, St Bartholomew's & Royal London School of Medicine, UK.
International Journal of Epidemiology
|February 19, 1999
Summary
High triglyceride levels significantly increase the risk of ruptured abdominal aortic aneurysm (AAA). Managing lipid profiles and other risk factors like blood pressure may reduce AAA mortality.
Area of Science:
- Cardiovascular epidemiology
- Vascular disease research
- Lipid metabolism and disease
Background:
- Investigating the link between serum lipid and apolipoprotein concentrations and ruptured abdominal aortic aneurysm (AAA).
- Understanding risk factors for AAA is crucial for preventative strategies.
Purpose of the Study:
- To determine the relationship between serum lipid and apolipoprotein concentrations and the risk of ruptured AAA.
- To identify potential modifiable risk factors for ruptured AAA.
Main Methods:
- A cohort study of 21,520 men aged 35-64 recruited between 1975-1982.
- Serum lipid and apolipoprotein levels were analyzed in 30 ruptured AAA cases and 150 matched controls.
- Data on smoking, BMI, and blood pressure were collected and analyzed.
Main Results:
- Triglyceride levels showed a strong association with ruptured AAA risk (RO10-90 = 12).
- Apolipoprotein B (apoB) and apoA1 also showed significant associations, while Lipoprotein (a) (Lp(a)) did not.
- High triglyceride levels remained a significant risk factor in multivariate analysis.
Conclusions:
- Triglyceride is identified as a potent risk factor for ruptured AAA.
- Modifying risk factors such as smoking, diet, and blood pressure could significantly decrease mortality from ruptured AAA.