Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Dose-response relation: relevance for clinical practice].

U Klinkhardt1, S Harder

  • 1Institut für Klinische Pharmakologie, Universitätsklinik Frankfurt am Main.

Medizinische Klinik (Munich, Germany : 1983)
|February 20, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strongly reducing magnesium(0) complexes.

Nature·2021
Same author

Dinitrogen complexation and reduction at low-valent calcium.

Science (New York, N.Y.)·2021
Same author

Home visits in the Danish High Risk and Resilience Study - VIA 7: assessment of the home environment of 508 7-year-old children born to parents diagnosed with schizophrenia or bipolar disorder.

Acta psychiatrica Scandinavica·2019
Same author

Osseointegration of dental implants in ectopic engineered bone in three different scaffold materials.

International journal of oral and maxillofacial surgery·2019
Same author

Acute effects of LSD on amygdala activity during processing of fearful stimuli in healthy subjects.

Translational psychiatry·2017
Same author

Reliability in Measuring Head Related Transfer Functions of Hearing Aids.

Acta acustica united with acustica : the journal of the European Acoustics Association (EEIG)·2017
Same journal

Medizinische Klinik (Munich, Germany : 1983)·2020
Same journal

Medizinische Klinik (Munich, Germany : 1983)·2020
Same journal

Medizinische Klinik (Munich, Germany : 1983)·2020
Same journal

[Not Available].

Medizinische Klinik (Munich, Germany : 1983)·2016
Same journal

[Not Available].

Medizinische Klinik (Munich, Germany : 1983)·2016
Same journal

[Not Available].

Medizinische Klinik (Munich, Germany : 1983)·2014
See all related articles

Dose-finding studies determine the optimal drug dosage by analyzing dose-response curves. This process evaluates efficacy and safety, considering the drug

Area of Science:

  • Pharmacology and Clinical Drug Development
  • Quantitative Pharmacology and Pharmacometrics

Context:

  • Dose-finding studies are crucial in early drug development, assessing efficacy and safety.
  • These studies are conducted in patients and, when applicable, healthy volunteers using surrogate models.

Purpose:

  • To establish the optimal dose range for new pharmaceutical compounds.
  • To characterize the drug's dose-response relationship, including key parameters like mean effective dose and maximal effect.

Summary:

  • Dose-response relationships are typically modeled using sigmoidal curves.
  • Interpretation requires considering the drug's intended clinical indications.
  • The risk-benefit ratio is assessed by analyzing the overlap between desired effects and adverse events, often quantified by the therapeutic index.

Related Experiment Videos

Impact:

  • Informs the design of subsequent clinical trials for efficacy and safety.
  • Facilitates informed decision-making regarding a drug's therapeutic potential and clinical utility.
  • Guides the assessment of a drug's safety profile within specific therapeutic contexts and in comparison to existing treatments.