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Related Experiment Videos

Mitochondrial pathology in human schizophrenic striatum: a postmortem ultrastructural study.

L Kung1, R C Roberts

  • 1Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore 21228, USA.

Synapse (New York, N.Y.)
|February 20, 1999
PubMed
Summary

Schizophrenia is linked to about 20% fewer mitochondria in the striatum, brain regions crucial for energy. Antipsychotic medication may help normalize these energy-producing organelles in schizophrenia patients.

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Area of Science:

  • Neuroscience
  • Cell Biology
  • Psychiatry

Background:

  • Studies indicate striatal abnormalities in schizophrenia, including reduced metabolism.
  • Mitochondria, responsible for cellular energy generation, are investigated as a potential factor in schizophrenia pathology.

Purpose of the Study:

  • To investigate mitochondrial pathology in the striatum of individuals with schizophrenia.
  • To determine if antipsychotic medication influences mitochondrial counts in schizophrenia.

Main Methods:

  • Postmortem striatal brain tissue from schizophrenic and control subjects was analyzed.
  • Mitochondria in electron micrographs of striatal neuropil were counted and digitized.

Main Results:

  • Schizophrenic subjects showed approximately 20% fewer mitochondrial profiles in the caudate and putamen compared to controls.

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  • Mitochondrial profiles per axon terminal appeared lower in schizophrenics not taking antipsychotic medication, suggesting a normalizing effect of treatment.
  • The structural integrity of mitochondria was similar between schizophrenic and control groups.

    • Conclusions:

    • Reduced mitochondrial numbers in the striatum may contribute to the observed metabolic deficits in schizophrenia.
    • Antipsychotic treatment might normalize mitochondrial deficits in the striatum of schizophrenia patients.
    • These findings suggest a potential anatomical basis for reduced striatal metabolism in schizophrenia.