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A tentative interpretation of electromyographic regional differences in bulbar- and limb-onset ALS
A Cappellari1, A Brioschi, S Barbieri
1Institute of Neurology, University of Milan Medical School, IRCCS Maggiore Hospital, Italy.
Neurology
|February 20, 1999
Abstract:
Electromyography (EMG) could be useful in defining regional motor neuron vulnerability in ALS. We performed EMG in 36 sporadic ALS patients (9 with bulbar-onset and 27 with limb-onset symptoms). Active denervation was more frequent in limb than in corresponding paraspinal muscles, in the thoracic paraspinal, and in the bulbo-cervical muscles in patients with bulbar-onset symptoms. These results are consistent with a regional motor neuron vulnerability along with a nerve length-dependent liability.