Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Gallstones: an intestinal disease?

K J Van Erpecum1, G P Van Berge-Henegouwen

  • 1Department of Gastroenterology, University Hospital Utrecht, Postbox 85500, 3508GA Utrecht, The Netherlands.

Gut
|February 23, 1999
PubMed
Summary

Impaired intestinal motility may contribute to gallstone formation by affecting bile acid levels and gallbladder function. Further research is needed to understand this link and common gallstone disease.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intra-gastric balloon with lifestyle modification: a promising therapeutic option for overweight and obese patients with metabolic dysfunction-associated steatotic liver disease.

Internal and emergency medicine·2023
Same author

Stauffer's syndrome: A true entity?

Clinics and research in hepatology and gastroenterology·2021
Same author

Retrieval of chronic hepatitis C patients. A manifesto for action to eliminate hepatitis C in the Netherlands: the CELINE project.

The Netherlands journal of medicine·2019
Same author

Strategies for achieving viral hepatitis C micro-elimination in the Netherlands.

Hepatology, medicine and policy·2018
Same author

Ribavirin steady-state plasma level is a predictor of sustained virological response in hepatitis C-infected patients treated with direct-acting antivirals.

Alimentary pharmacology & therapeutics·2017
Same author

How the concept of biochemical response influenced the management of primary biliary cholangitis over time.

The Netherlands journal of medicine·2016

Area of Science:

  • Gastroenterology
  • Hepatology
  • Motility Disorders

Background:

  • Gallstone formation is a common condition in Western populations.
  • Impaired intestinal motility is a potential contributing factor, possibly by altering biliary deoxycholate levels.
  • The role of intestinal motility in gallstone pathogenesis requires further investigation.

Purpose of the Study:

  • To explore the connection between intestinal motility and gallstone formation.
  • To highlight the importance of the gallbladder and biliary tract as a critical interface between the liver and intestine.
  • To encourage interdisciplinary research between hepatology and gastrointestinal motility specialists.

Main Methods:

  • Review of current evidence linking intestinal motility to gallstone formation.
  • Conceptual framework comparing the gallbladder/biliary tract to a political 'border'.
  • Call for combined research efforts.

Main Results:

  • Current evidence suggests impaired intestinal motility influences factors related to gallstone formation.
  • A primary intestinal defect in gallstone pathogenesis has not been definitively established.
  • The gallbladder and biliary tract are key sites for interactions impacting liver and intestinal health.

Conclusions:

  • Understanding the interplay between intestinal motility and biliary physiology is crucial for addressing gallstone disease.
  • Interdisciplinary collaboration is essential to overcome current knowledge gaps.
  • Further research into the role of intestinal motility could unlock new insights into gallstone pathogenesis.

Related Experiment Videos