Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Decrease in enkephalin levels in psoriatic lesions after calcipotriol and mometasone furoate treatment.

J B Nissen¹, W W Avrach, E S Hansen

¹Department of Dermatology, Marselisborg Hospital, Copenhagen, Denmark.

Dermatology (Basel, Switzerland)

|February 23, 1999

Summary

Topical calcipotriol and mometasone furoate reduced methionine-enkephalin (enk) levels in psoriasis lesions, correlating with clinical improvement. These findings suggest enkephalins play a role in psoriasis pathogenesis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Plasma haem oxygenase-1 may represent a first-in-class biomarker of oxidative stress in rheumatoid arthritis.

Scandinavian journal of rheumatology·2024

Same author

Reduced prescription of TNF-inhibitors in chronic arthritis based on therapeutic drug monitoring: A randomized controlled trial.

Scandinavian journal of rheumatology·2022

Same author

Baseline serum levels of IgA anti-cyclic citrullinated protein antibodies in early rheumatoid arthritis predict radiographic progression after 11 years of treatment: a secondary analysis of the CIMESTRA study.

Scandinavian journal of rheumatology·2022

Same author

Serum 14-3-3η as predictor of clinical remission and progression of structural damage in early rheumatoid arthritis following a treat-to-target strategy in a randomized controlled trial.

Scandinavian journal of rheumatology·2022

Same author

Increased synovial galectin-3 induce inflammatory fibroblast activation and osteoclastogenesis in patients with rheumatoid arthritis.

Scandinavian journal of rheumatology·2022

Same author

Effect of initiating biologics compared to intensifying conventional DMARDs on clinical and MRI outcomes in established rheumatoid arthritis patients in clinical remission: Secondary analyses of the IMAGINE-RA trial.

Scandinavian journal of rheumatology·2021

Area of Science:

Dermatology
Immunology
Biochemistry

Background:

Enkephalins, opioid peptides, modulate immune responses and inhibit keratinocyte proliferation.
Elevated enkephalin levels are observed in psoriatic lesions.
Psoriasis involves complex immune and epidermal processes.

Purpose of the Study:

To investigate the impact of topical calcipotriol and mometasone furoate on methionine-enkephalin (enk) levels in psoriatic lesions.
To correlate treatment-induced changes in enk levels with clinical and histological outcomes.

Main Methods:

Twelve psoriasis patients received 14-day topical treatment with calcipotriol and mometasone furoate, with or without hydrocolloid occlusion.
Keratome biopsies were analyzed for enk quantification via radioimmunoassay.

Related Experiment Videos

Punch biopsies facilitated immunohistochemical analysis of immune cells.

Main Results:

Both calcipotriol and mometasone furoate demonstrated comparable clinical improvement, enhanced by occlusion.
Enkephalin levels decreased significantly with both treatments, with greater reduction under occlusion (26-86% for calcipotriol, 16-63% for mometasone furoate).
Decreased enk levels correlated with clinical improvement but not directly with all histological changes.

Conclusions:

Topical calcipotriol and mometasone furoate effectively reduce elevated enkephalin levels in psoriatic lesions.
The reduction in enkephalins parallels clinical symptom improvement in psoriasis.
Enkephalins may be implicated in the pathogenesis of psoriasis, influencing epidermal differentiation and inflammation.