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Predicting chronic lung disease in very low birthweight infants: comparison of 3 scores
J Hentschel1, C Friedel, R F Maier
1Dept. of Neonatology, Charité (Virchow Klinikum), Humboldt-University, Berlin, Germany. Juliane.Hentschel@insel.ch
Aim:
To evaluate 3 scores in their ability to predict Chronic Lung Disease (CLD) in very low birthweight (VLBW) infants.
Methods:
The records of 188 VLBWs admitted to neonatal intensive care within two years were retrospectively reviewed. Two mortality scores -the CRIB (clinical risk index for babies) score and the Berlin admission score- and one morbidity score developed to predict CLD (Sinkin score) were assigned to each infant. Areas (AUC) under receiver operating characteristic (ROC) curves were used for comparison.
Results:
The Sinkin score and the Berlin admission score had AUCs of 89.0 and 85.8% to predict CLD ("alive in oxygen at 28 days of life"). The AUCs were 87.7 and 81.2%, respectively, using the CLD definition "alive in oxygen at 36 weeks gestational age", the CRIB had an AUC of 77.0%.
Conclusion:
To enroll patients in trials aimed at early interference with the course of CLD, the Berlin admission score or the Sinkin score could be used.