Related Experiment Videos
No pathogenic mutations in the persyn gene in Parkinson's disease
S Lincoln1, K Gwinn-Hardy, J Goudreau
1Mayo Clinic Jacksonville, FL 32084, USA.
Neuroscience Letters
|February 23, 1999
Abstract:
The persyn (gamma-synuclein) gene is highly homologous to the alpha-synuclein gene and is highly expressed in the nervous system. It is therefore, an excellent candidate gene for Parkinson's disease. However, we have sequenced the gene in a large number of families with parkinsonism and failed to find pathogenic mutations.