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Effect of codeine on oro-cecal transit time in Chinese healthy volunteers in comparison with Caucasian subjects
Q Y Yue1, J Hasselström, J O Svensson
1Department of Clinical Pharmacology, Huddinge University Hospital, Karolinska Institute, Sweden.
Objectives:
To evaluate the effect of codeine on oro-cecal transit time (OCTT) in Chinese subjects.
Methods:
OCTT was measured with the hydrogen breath test in 12 Chinese healthy volunteers on two occasions: after placebo and after a single oral dose of codeine 50 mg. Codeine and its metabolites in urine were measured by HPLC. The Results of this study were compared with those previously obtained from Caucasian subjects.
Results And Conclusion:
The mean OCTT increased significantly after a single oral dose of codeine 50 mg [2.6 (1.2) h] compared with placebo [1.9 (0.6) h] in the Chinese subjects (P = 0.05). The increase in OCTT after codeine was similar in the Caucasian [0.9 (0.8) h] and in the Chinese subjects [0.7 (0.9) h]. However, the Chinese subjects had a significantly longer OCTT after placebo [1.9 (0.6) h] compared with the Caucasian subjects [1.3 (0.6) h, P < 0.05], possibly due to different environmental factors.
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