Hemodynamic and mechanical performance of arterial grafts assessed by numerical simulation: a design oriented study

The hemodynamic and mechanical characteristics of an end-to-end implanted prosthesis for a small artery were theoretically investigated. The changes in the main physical and geometrical properties of the prosthesis were simulated by means of a numerical model of arterial hemodynamics. Variation in the pressure-radius curve due to changes in lumen size, wall thickness, elasticity, and tapering were considered. The effects of such changes on pressure, flow, and wall stresses during the cardiac cycle were evaluated. To avoid superimposing the effects, only 1 of the graft properties was varied with respect to a reference condition in each simulation. A prosthesis with a reduced lumen size (20%) was subjected to higher shear stress, which was dangerously doubled. Wall thickening (200%) primarily determined decreased circumferential stress (300%) and increased wall shear stress (48%) because it caused a reduction of the graft lumen size. The time averages of flow and pressure over the cardiac cycle were not significantly influenced by the simulated changes, being imposed primarily by the proximal and distal circulations.