Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

M161Ag is a potent cytokine inducer with complement activating function (review).

M Matsumoto1, T Seya

  • 1Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Higashinari-ku, Osaka 537, Japan.

International Journal of Molecular Medicine
|February 24, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of oxidative stress on induced tolerance to ischemia in gerbil hippocampal neurons.

Brain research·1992
Same author

Purification and characterization of a novel growth factor (FF-GF) synthesized by a rat hepatoma cell line, FF101.

Biochemical and biophysical research communications·1992
Same author

Vitamin E inhibits protein oxidation in skeletal muscle of resting and exercised rats.

Biochemical and biophysical research communications·1992
Same author

Effect of local cyanide perfusion on rat striatal extracellular dopamine and its metabolites as studied by in vivo brain microdialysis.

Neuroscience letters·1992
Same author

Two modes of homologous C3 deposition on Ramos Burkitt's lymphoma cell substrains co-expressing DAF (CD55), CD59, and CR2 (CD21), and on cells lacking them.

International immunology·1992
Same author

Alpha-fetoprotein-producing immature mediastinal teratoma showing rapid and massive recurrent growth in an adult.

Acta pathologica japonica·1992
Same journal

Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review).

International journal of molecular medicine·2026
Same journal

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway.

International journal of molecular medicine·2026
Same journal

Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review).

International journal of molecular medicine·2026
Same journal

Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review).

International journal of molecular medicine·2026
Same journal

ABCG2 transporter: Structural and functional associations with gout (Review).

International journal of molecular medicine·2026
Same journal

Research progress on the chemical and pharmacological effects of <i>Semen Strychni</i> (Review).

International journal of molecular medicine·2026
See all related articles

A novel protein, M161Ag, produced by Mycoplasma fermentans infection in tumor cells, activates the human immune system. This bacterial protein induces key cytokines, offering potential for novel cancer immunotherapies.

Area of Science:

  • Immunology
  • Microbiology
  • Molecular Biology

Background:

  • A novel membrane-associated protein, M161Ag, is expressed on human malignant cells during apoptosis.
  • M161Ag exhibits unique prokaryotic features, including TGA codon translation and N-terminal lipidation.

Purpose of the Study:

  • To investigate the immunomodulatory functions of M161Ag.
  • To determine the origin and mechanism of M161Ag expression in human cells.

Main Methods:

  • Analysis of M161Ag's effect on human complement and cytokine induction (IL-1β, TNF-α, IL-6, IL-10, IL-12) in peripheral blood monocytes.
  • Genomic Southern analysis to confirm the Mycoplasma fermentans origin of M161Ag.
  • Examination of M161Ag's genetic elements, including promoter and ribosomal binding sites.

Related Experiment Videos

Main Results:

  • M161Ag activates human complement and induces a range of pro-inflammatory and regulatory cytokines.
  • The protein's genetic sequence and post-translational modifications indicate a prokaryotic origin.
  • Genomic analysis confirmed M161Ag expression is linked to Mycoplasma fermentans infection.

Conclusions:

  • Latent Mycoplasma fermentans infection in tumor cells leads to M161Ag production, activating the host immune system.
  • Bacterial proteins like M161Ag with immuno-regulatory functions represent potential candidates for therapeutic development.