Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nongonococcal urethritis--a new paradigm.

G R Burstein1, J M Zenilman

  • 1Department of Molecular Microbiology and Immunology, Johns Hopkins University, Baltimore, Maryland 21205, USA. gburstei@welchlink.welch.jhu.edu

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|February 24, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Safety and pharmacokinetics of XOMA 3AB, a novel mixture of three monoclonal antibodies against botulinum toxin A.

Antimicrobial agents and chemotherapy·2014
Same author

What do we need to learn for policy decision-making on sexually transmitted infections prevention and treatment in Israel?

International journal of STD & AIDS·2012
Same author

PCR offers no advantage over culture for microbiologic diagnosis in cellulitis.

Infection·2012
Same author

Prostate involvement during sexually transmitted infections as measured by prostate-specific antigen concentration.

British journal of cancer·2011
Same author

New horizons for cutaneous microbiology: the role of biofilms in dermatological disease.

The British journal of dermatology·2011
Same author

Real-time PCR assays compared to culture-based approaches for identification of aerobic bacteria in chronic wounds.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2010

Nongonococcal urethritis (NGU) diagnosis and management are evolving. Urine-based nucleic acid amplification tests and azithromycin offer improved detection and treatment for men with NGU.

Area of Science:

  • Urology
  • Infectious Diseases
  • Microbiology

Background:

  • Urethritis in men is traditionally classified as gonococcal or nongonococcal (NGU).
  • Key pathogens for NGU include Chlamydia trachomatis and Ureaplasma urealyticum, with occasional involvement of Trichomonas vaginalis.
  • In up to 50% of cases, the causative organism for NGU remains unidentified.

Purpose of the Study:

  • To review recent advancements in the diagnosis and management of NGU.
  • To discuss the application of new diagnostic and therapeutic strategies in various clinical settings.
  • To re-evaluate the traditional classification of urethritis in light of new diagnostic technologies.

Main Methods:

  • Review of recent literature on NGU diagnosis and management.

Related Experiment Videos

  • Discussion of noninvasive urine-based nucleic acid amplification tests (NAATs).
  • Evaluation of antibiotic treatment options, including azithromycin and tetracyclines.

    • Main Results:

    • Urine-based NAATs may necessitate a reclassification of urethritis, moving beyond the gonococcal urethritis/NGU dichotomy.
    • Diagnostic testing for Chlamydia is crucial due to public health implications like partner notification.
    • A single 1-g dose of azithromycin is therapeutically equivalent to tetracyclines for NGU treatment, potentially improving patient compliance.

    Conclusions:

    • Advances in diagnostic methods, particularly urine-based NAATs, are transforming NGU management.
    • Prompt and accurate diagnosis of NGU, especially Chlamydia trachomatis, is vital for public health.
    • Azithromycin offers a convenient and effective treatment option for NGU, comparable to traditional therapies.