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The role of gene therapy. Fact or fiction?
T S Muzzonigro1, S C Ghivizzani, P D Robbins
1Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania, USA.
Clinics in Sports Medicine
|February 24, 1999
Abstract:
Current research in molecular biology and genetics has dramatically advanced the understanding of the cellular events involved in homeostasis, disease, injury, and healing processes of the tissues of the musculoskeletal system. Recently, genetic predispositions to diseases have been described which offer novel means to address musculoskeletal disorders. Growth factors and cytokines have been identified as key elements in both the injured and healing states. Gene therapy offers an elegant solution to the delivery of therapeutic proteins to the site of disease or injury.