Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug-induced urolithiasis.

C A Osborne1, J P Lulich, J W Bartges

  • 1Minnesota Urolith Center, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, USA.

The Veterinary Clinics of North America. Small Animal Practice
|February 24, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Radiographic diagnoses in 80 cats before and 73 cats after unobstructing the urethra.

The Journal of small animal practice·2021
Same author

Pyloric outflow obstruction secondary to sclerosing encapsulating peritonitis in a dog.

Australian veterinary journal·2019
Same author

Axillary web syndrome following breast cancer surgery: symptoms, complications, and management strategies.

Breast cancer (Dove Medical Press)·2018
Same author

Lymphspiration: The Axillary Web and Its Lymphatic Origin.

Lymphology·2018
Same author

Ectopic Bone as a Nidus for Calcium Oxalate Urocystolithiasis in a Cat.

Journal of veterinary internal medicine·2017
Same author

ACVIM Small Animal Consensus Recommendations on the Treatment and Prevention of Uroliths in Dogs and Cats.

Journal of veterinary internal medicine·2016
Same journal

Regulation of Artificial Intelligence in Veterinary Medicine.

The Veterinary clinics of North America. Small animal practice·2026
Same journal

Practical Steps Toward Antimicrobial Stewardship for the General Practitioner.

The Veterinary clinics of North America. Small animal practice·2026
Same journal

Using Evidence-Based Veterinary Medicine and Artificial Intelligence to Support Clinical Decision Making in Veterinary Practice.

The Veterinary clinics of North America. Small animal practice·2026
Same journal

Feline Asthma-Update on Diagnosis and Treatment Recommendations.

The Veterinary clinics of North America. Small animal practice·2026
Same journal

Disease Prediction and Precision Veterinary Medicine: Applications, Opportunities, and Limitations of Artificial Intelligence in Small Animal Practice.

The Veterinary clinics of North America. Small animal practice·2026
Same journal

The Moving Target of Companion Animal Infectious Diseases: Emerging Threats and Evolving Solutions.

The Veterinary clinics of North America. Small animal practice·2026
See all related articles

Certain diagnostic and therapeutic drugs can increase the risk of urolithiasis (kidney stone formation) by altering urine chemistry, affecting kidney function, or directly forming stones.

Area of Science:

  • Nephrology
  • Pharmacology
  • Urology

Background:

  • Urolithiasis is a common condition with multifactorial causes.
  • The role of diagnostic and therapeutic drugs in urolithiasis development is increasingly recognized.

Purpose of the Study:

  • To elucidate the mechanisms by which medications may contribute to urolithiasis.
  • To identify key drug-induced alterations in physiological processes relevant to stone formation.

Main Methods:

  • Review of pharmacological and physiological pathways involved in urolithiasis.
  • Analysis of how drug actions can influence urine composition and kidney function.

Main Results:

  • Drugs can alter urine pH, impacting the solubility of stone-forming substances.

Related Experiment Videos

  • Medications can modify glomerular filtration rate and tubular handling of endogenous substances, affecting stone promoters and inhibitors.
  • Direct precipitation of drugs or their metabolites can contribute to urolith formation.

    • Conclusions:

    • Diagnostic and therapeutic agents represent a significant, often overlooked, risk factor for urolithiasis.
    • Understanding these drug-induced mechanisms is crucial for prevention and management strategies.