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Updated: Oct 12, 2026

Functional Evaluation of Biological Neurotoxins in Networked Cultures of Stem Cell-derived Central Nervous System Neurons
Published on: February 5, 2015
Neuromuscular effects of low level exposures to Sarin, pyridostigmine, DEET, and chlorpyrifos
C T Olson1, J A Blank, R G Menton
1Battelle Memorial Institute, Medical Research and Evaluation Facility, Columbus, OH 43201-2693, USA.
Abstract:
A study is being initiated to investigate subtle neurobehavioral effects and neuropathology in rats due to exposure to combinations of low levels of Sarin (GB), N,N-diethyl-m-toluamide (DEET), chlorpyrifos (CPF), and pyridostigmine bromide (PB). A similar study is being initiated in rhesus monkeys to investigate neurophysiologic effects and neuromuscular pathology due to exposure to a combination of GB, DEET, CPF, and PB, along with vaccination with botulinum toxoid. A description of these studies is presented.
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