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Solubility, 1H-NMR, and molecular mechanics of mebendazole with different cyclodextrins
D Díaz1, M J Bernad Bernad, J Gracia-Mora
1Facultad de Química, Departamento de Química Inorgánica, UNAM, Delegación Coyoacan, México.
Drug Development and Industrial Pharmacy
|February 24, 1999
Abstract:
The solubility behavior and binding constants (Kass) of mebendazole with alpha-, beta-, gamma-, and hydroxypropyl-beta-cyclodextrins (HP-beta-CD) have been investigated in simulated intestinal juice by the Higuchi and Connors method. AL diagrams have been obtained. The equilibrium has also been studied in simulated gastric fluid with HP-beta-CD. The phase solubility, 1H-NMR, and molecular mechanics studies revealed the formation of a 1:1 complex.