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[Two cases of retroperitoneal functioning paraganglioma].

T Maruyama1, H Kuwae, T Ogino

  • 1Department of Urology, Takarazuka City Hospital.

Hinyokika Kiyo. Acta Urologica Japonica
|February 24, 1999
PubMed
Summary

This study presents two cases of retroperitoneal paraganglioma, a rare tumor. Surgical removal effectively treated these functioning tumors, resolving patient symptoms and normalizing hormone levels.

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Area of Science:

  • Endocrinology
  • Oncology
  • Surgical Pathology

Background:

  • Retroperitoneal paragangliomas are rare neuroendocrine tumors arising from chromaffin cells.
  • Functioning paragangliomas secrete catecholamines, leading to significant clinical manifestations.

Observation:

  • Two patients presented with symptoms suggestive of catecholamine excess, including hypertension, headaches, and abdominal pain.
  • Diagnostic imaging (CT, MRI, angiography) identified large retroperitoneal masses.
  • Elevated serum and urine catecholamine levels confirmed hormonally active tumors.

Findings:

  • Histopathological examination confirmed paraganglioma in both surgically resected tumors.
  • Postoperative resolution of symptoms and normalization of catecholamine levels were observed.

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  • Case 2 demonstrated improvement in diabetes control after tumor removal.

    • Implications:

    • Surgical resection is an effective treatment for symptomatic retroperitoneal paragangliomas.
    • Early diagnosis and intervention can prevent severe complications associated with catecholamine excess.
    • This case series highlights the importance of considering paraganglioma in patients with unexplained hypertension and abdominal masses.