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Cancer risk in collagenous colitis
J L Chan1, A C Tersmette, G J Offerhaus
1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Inflammatory Bowel Diseases
|February 24, 1999
Summary
Collagenous colitis patients do not face an increased risk of colorectal cancer. However, women with this condition show a higher relative risk for lung cancer, warranting further investigation.
Area of Science:
- Gastroenterology
- Oncology
- Epidemiology
Background:
- Collagenous colitis is a chronic inflammatory bowel disease.
- Inflammatory bowel disorders are linked to increased malignancy risk.
- Cancer risk in collagenous colitis remains unevaluated.
Purpose of the Study:
- To assess colorectal and extracolonic malignancy risk in collagenous colitis patients.
- To compare cancer incidence and mortality rates with the general population.
Main Methods:
- Analysis of 117 collagenous colitis patients from the Johns Hopkins Registry.
- Person-year analysis comparing tumor incidence and mortality rates.
- Adjustment for general population data.
Main Results:
- No colorectal cancer cases observed post-diagnosis during a mean 7-year follow-up.
- Lifetime relative risk of colorectal cancer was not elevated (RR 0.52).
- Increased relative risk of lung cancer noted in women (RR 3.7, p=0.048).
- Overall malignancy and mortality rates did not differ from the general population.
Conclusions:
- Collagenous colitis is not associated with an increased lifetime risk of colorectal cancer.
- An elevated lung cancer risk in women with collagenous colitis suggests further research into factors like smoking.