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Related Experiment Videos

Angiotensin-converting-enzyme gene insertion/deletion polymorphism and response to physical training.

H Montgomery1, P Clarkson, M Barnard

  • 1Centre for Cardiovascular Genetics, University College London, Rayne Institute, UK. h.montgomery@ucl.ac.uk

Lancet (London, England)
|February 24, 1999
PubMed
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Individuals with the II genotype, indicating lower angiotensin-converting enzyme (ACE) activity, showed greater muscle and fat mass gains during intense exercise. This suggests enhanced metabolic efficiency and improved training response.

Area of Science:

  • Exercise physiology
  • Human genetics
  • Metabolic studies

Background:

  • The role of local renin-angiotensin systems in skeletal muscle and adipose tissue is poorly understood.
  • A common polymorphism in the human angiotensin-converting enzyme (ACE) gene (insertion/deletion) influences ACE activity and training response.

Purpose of the Study:

  • To investigate the association between the ACE gene insertion/deletion polymorphism and changes in body composition.
  • To explore the metabolic effects of local renin-angiotensin systems during intensive exercise.

Main Methods:

  • Three independent methods (bioimpedance, skinfold thickness, MRI) assessed body composition changes.
  • Study involved young male army recruits undergoing 10 weeks of intensive physical training.

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Main Results:

  • The II genotype group exhibited a significantly greater anabolic response in fat mass (0.55 kg) and non-fat mass (1.31 kg) compared to groups with D alleles.
  • Body morphology changes during training were dependent on ACE genotype.

Conclusions:

  • The II genotype, linked to lower ACE activity, may promote positive energy balance and enhanced metabolic efficiency during rigorous training.
  • This finding could explain benefits observed with ACE inhibitor therapies.