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Updated: Aug 9, 2026

Fixed Volume or Fixed Pressure: A Murine Model of Hemorrhagic Shock
Published on: June 6, 2011
The effects of varying fluid volume and rate of resuscitation during uncontrolled hemorrhage
1Department of Surgery, Texas Tech University Health Sciences Center, Lubbock 79430, USA.
Background:
The role of rate and volume of infusion in survival from experimental uncontrolled hemorrhage was evaluated.
Methods:
Hemorrhage was initiated using tail resection in 43 female rats assigned to the following five groups: nonresuscitated; resuscitated with moderate volume, slower rate; resuscitated with moderate volume, faster rate; resuscitated with high volume, slower rate; and resuscitated with high volume, faster rate.
Results:
A trend toward improved survival was noted with faster rate of infusion (60 vs. 33.3% survival rate with moderate volume and 28.6 vs. 12.5% with high volume, compared with 16.7% in the nonresuscitated animals).
Conclusion:
Rapid infusion of moderate volume of isotonic saline improved survival in uncontrolled hemorrhage. Extreme volumes, infused rapidly, also resulted in higher survival rates compared with those observed in nonresuscitated rats.
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