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Brain-gut interactions: implications for newer therapy.

E A Mayer1, L Chang, T Lembo

  • 1UCLA/CURE Neuroenteric Disease Program, Division of Digestive Diseases, UCLA School of Medicine, Los Angeles, CA 90073, USA. emayer@ucla.edu

The European Journal of Surgery. Supplement. : = Acta Chirurgica. Supplement
|February 24, 1999
PubMed
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Functional GI disorders lack effective treatments due to inadequate models. New research focuses on brain-gut interactions, identifying potential drug targets in the nervous system for improved therapies.

Area of Science:

  • Neurogastroenterology
  • Pharmacology
  • Gastroenterology

Background:

  • Functional gastrointestinal (GI) disorders are prevalent, costly, and lack effective therapies.
  • Current treatments are based on insufficient disease models, and clinical trials often have design flaws.
  • A new model implicates altered brain-gut interactions in functional GI disorders.

Purpose of the Study:

  • To review the current understanding of functional GI disorders.
  • To identify potential pharmacological targets based on the brain-gut interaction model.
  • To discuss the implications for developing novel therapeutic strategies.

Main Methods:

  • Literature review of functional GI disorders and brain-gut interactions.
  • Analysis of potential therapeutic targets within the peripheral and central nervous systems.

Related Experiment Videos

  • Synthesis of current research to propose a framework for treatment development.

    • Main Results:

    • Altered brain-gut interactions are central to functional GI disorders.
    • Potential drug targets include receptors on visceral afferent nerves, spinal cord neurons, and supraspinal sites.
    • Pharmacological strategies can be tailored to peripheral or central nervous system targets.

    Conclusions:

    • Despite incomplete understanding of mechanisms, specific targets offer promise for treating functional GI disorders.
    • Novel therapies can be developed by targeting receptors and channels in the brain-gut axis.
    • Effective treatments may emerge regardless of whether the primary pathophysiology is central or peripheral.