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Presurgical contribution of quantitative stereotactic positron emission tomography in temporo limbic epilepsy
1Epilepsy and Brain Mapping Program, Cedars-Sinai Medical Office Towers, Los Angeles, California, USA.
Background:
We quantified the interictal metabolic changes associated with temporal lobe epilepsy by using an accurate stereotactic method.
Methods:
We selected 16 patients who had proven unilateral focal or regional temporal onset defined by SEEG criteria. Each patient underwent stereotactic MRI and stereotactic [18 fluoro] fluorodeoxyglucose positron emission tomography (PET).
Results:
Asymmetries (mean, +/- SD) were found in mesio-temporal structures: amygdala (-0.033+/-0.027, p = 0.0002), hippocampus (-0.035+/-0.032, p = 0.0006), and superior temporal gyrus (-0.036+/-0.032, p = 0.0004). Four of the sixteen patients had previously had unlocalized qualitative nonstereotactic PET analysis.
Conclusions:
The quantitative stereotactical PET method allows a higher resolution study of mesio-temporal structures.