Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Racial differences in the outcome of left ventricular dysfunction.

D L Dries1, D V Exner, B J Gersh

  • 1Clinical Trials Scientific Research Group, Division of Epidemiology and Clinical Application, National Heart, Lung, and Blood Institute, Bethesda, MD 20892-7936, USA. ddries@aol.com

The New England Journal of Medicine
|February 25, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Influence of albuminuria on cardiovascular risk in patients with stable coronary artery disease. Circulation 116: 2687-2693, 2007.

Clinical journal of the American Society of Nephrology : CJASN·2023
Same author

Cardiac troponin is associated with cardiac outcomes in men and women with atrial fibrillation, insights from the ARISTOTLE trial.

Journal of internal medicine·2020
Same author

Effect of Low-Dose Rapamycin on Senescence Markers and Physical Functioning in Older Adults with Coronary Artery Disease: Results of a Pilot Study.

The Journal of frailty & aging·2016
Same author

D-dimer and risk of thromboembolic and bleeding events in patients with atrial fibrillation--observations from the ARISTOTLE trial.

Journal of thrombosis and haemostasis : JTH·2014
Same author

Diabetes, incretin hormones and cardioprotection.

Heart (British Cardiac Society)·2014
Same author

Vitamin D supplementation is associated with improved modulation of cardiac autonomic tone in healthy humans.

International journal of cardiology·2014
Same journal

Ebola at 50 - Lessons for Outbreak Response and Preparedness.

The New England journal of medicine·2026
Same journal

Ianalumab plus Eltrombopag in Immune Thrombocytopenia. Reply.

The New England journal of medicine·2026
Same journal

Ianalumab plus Eltrombopag in Immune Thrombocytopenia.

The New England journal of medicine·2026
Same journal

Hypertension Control in Low-Income Patients. Reply.

The New England journal of medicine·2026
Same journal

Hypertension Control in Low-Income Patients.

The New England journal of medicine·2026
Same journal

Hypertension Control in Low-Income Patients.

The New England journal of medicine·2026
See all related articles

Black patients with left ventricular dysfunction face higher mortality and heart failure progression risks than white patients. This suggests potential racial disparities in the condition's natural history and outcomes.

Area of Science:

  • Cardiology
  • Clinical Research
  • Health Disparities

Background:

  • Population studies indicate higher mortality rates for Black patients with congestive heart failure compared to white patients.
  • Attributed factors include differences in heart failure severity, causes, management, comorbidities, and socioeconomic status.
  • This study investigates potential racial differences in the natural history of left ventricular dysfunction.

Purpose of the Study:

  • To retrospectively analyze outcomes of left ventricular systolic dysfunction in Black and white participants within the Studies of Left Ventricular Dysfunction (SOLVD) trials.
  • To determine if racial differences persist in outcomes despite standardized therapy and follow-up.

Main Methods:

  • Retrospective analysis of data from the SOLVD prevention and treatment trials.

Related Experiment Videos

  • Inclusion of both asymptomatic and symptomatic patients with left ventricular systolic dysfunction.
  • Standardized therapy and follow-up protocols were applied to all participants.

    • Main Results:

    • Black patients exhibited higher overall mortality rates in both the SOLVD prevention and treatment trials compared to white patients.
    • After adjusting for covariates, Black patients consistently showed a higher risk of all-cause mortality in both trials.
    • Black patients also faced a higher risk of death due to pump failure and the combined endpoint of death or hospitalization for heart failure.

    Conclusions:

    • Black individuals with mild-to-moderate left ventricular systolic dysfunction appear to have a greater risk of heart failure progression and all-cause mortality compared to similarly treated white individuals.
    • These findings suggest potential racial variations in the outcomes of both asymptomatic and symptomatic left ventricular systolic dysfunction.