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Ki-1+ large-cell anaplastic lymphoma after Ewing sarcoma
H C Rossbach1, W Chamizo, A K Walling
1Division of Pediatric Hematology/Oncology, All Children's Hospital, St. Petersburg, Florida, USA.
Purpose:
A large cell anaplastic lymphoma that developed after treatment of a Ewing sarcoma (ES) is described.
Patient:
An 11-year-old girl with a pelvic ES developed a large cell, Ki-1+, anaplastic lymphoma in the same anatomic location 10 months after multimodal therapy.
Results:
ES recurred in the primary site 16 months after allogeneic marrow transplantation and 3.5 years after initial diagnosis, but the patient remains in remission from her lymphoma.
Conclusion:
The occurrence of lymphoma and ES in a short time interval in the same patient is very unusual. Whether etiologic factors other than chemoradiotherapy, including genetic disposition, play a role remains to be elucidated.
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