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Side effects of triazolam in children
S E Coldwell1, K Awamura, P Milgrom
1Department of Dental Public Health Sciences, University of Washington, Seattle, USA.
Purpose:
This study examined the incidence of side effects occurring with three doses of orally administered triazolam in children undergoing restorative dental procedures.
Methods:
Thirty children, aged 39-81 months, participated in the study. The children were pretested for gait ataxia, amnesia, visual acuity, stereoscopic depth perception, and diplopia during a screening session. In a subsequent appointment, children received one of three triazolam dosages (0.005, 0.015, and 0.030 mg/kg) prior to dental treatment. Dosage assignment was random and double blind. Each child received a single triazolam dosage. Tests for gait ataxia, amnesia, and visual disturbances were repeated following drug administration.
Results:
The proportion of children experiencing ataxia, amnesia, and diplopia increased with increasing triazolam dosages. The 0.030-mg/kg triazolam dosage impaired visual acuity and stereoscopic depth perception.
Conclusion:
Triazolam produces ataxia, amnesia, and diplopia in a dose-dependent manner in children.