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[Nitric oxide in dengue pathology].

M Rodriguez-Ortega1

  • 1Facultad de Medicina, Instituto de Biomedicina, U.C.V. Providencia a San Nicolás, San José, Caracas, Venezuela. mrodri@telcel.net.ve

Acta Cientifica Venezolana
|February 25, 1999
PubMed
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Nitric oxide (NO) plays a dual role in cell function and is linked to severe diseases. This study explores the connection between NO production and the pathology of severe dengue virus infection.

Area of Science:

  • Biochemistry and Molecular Biology
  • Immunology
  • Pathology

Context:

  • Nitric oxide (NO) is a critical signaling molecule with diverse roles, including cytotoxic and cytoprotective functions.
  • Dysregulated NO production is implicated in various critical illnesses like septic, anaphylactic, and hemorrhagic shock.
  • Dengue virus infection presents a spectrum of illness, ranging from mild dengue fever to severe dengue hemorrhagic fever and dengue shock.

Purpose:

  • To discuss evidence linking nitric oxide (NO) to the pathogenesis of severe dengue virus infection.
  • To explore the role of NO in the complex pathophysiology of severe dengue.

Summary:

  • Nitric oxide (NO) is a key mediator in cellular processes, with altered levels associated with severe pathologies.
  • Severe dengue virus infection, characterized by dengue hemorrhagic fever and dengue shock, is explored in relation to NO.

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  • Evidence suggests a significant link between nitric oxide pathways and the development of severe dengue disease.

    • Impact:

    • Highlights the potential role of NO as a biomarker or therapeutic target in severe dengue.
    • Provides insights into the molecular mechanisms underlying dengue hemorrhagic fever and dengue shock.
    • Contributes to understanding the pathophysiology of viral hemorrhagic fevers and associated circulatory collapse.