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Heart aneurysm in Chagas' disease.

J A de Oliveira1

  • 1Department of Pathology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil. jamdoliv@fmrp.usp.br

Revista Do Instituto De Medicina Tropical De Sao Paulo
|February 25, 1999
PubMed
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This study investigated the apical lesion in Chagas' disease, suggesting an ischemic factor in its development. Hearts with aneurysms showed significantly higher scores, indicating reduced myocardial irrigation.

Area of Science:

  • Cardiology
  • Pathology
  • Chagas' Disease Research

Background:

  • The pathogenesis of the apical lesion in Chagas' disease remains unclear.
  • Previous studies did not establish a link between lesion frequency and heart weight, suggesting vascular factors were not primary.

Purpose of the Study:

  • To evaluate relative coronary insufficiency as a potential factor in apical lesion development.
  • To establish a more sensitive morphological assessment of myocardial ischemia in Chagas' cardiopathy.

Main Methods:

  • Prospective study of 41 autopsy-collected human hearts.
  • Injected colored gels into coronary arteries to map vascular beds.
  • Calculated Right Ventricle/Left Ventricle (RV/LV) mass ratio and Right Coronary Artery/Ventricular Weight (RC/VW) mass ratio.

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  • Developed a composite score correlating with myocardial irrigation.

    • Main Results:

    • A score was developed to assess myocardial irrigation.
    • A rightward deviation in lesion frequency was observed when plotted against the score.
    • Hearts with apical aneurysms exhibited significantly higher ischemia scores.

    Conclusions:

    • Suggests a significant ischemic factor in the pathogenesis of the apical lesion in Chagas' cardiopathy.
    • The developed scoring system offers a more sensitive morphological evaluation of relative ischemia.