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Related Experiment Videos

Decrease of serum levels of soluble CD23 during immunotherapy in patients with perennial allergic rhinitis.

A Tanaka1, Y Ohashi, Y Nakai

  • 1Department of Otolaryngology, Osaka City University Medical School, Abeno, Osaka, Japan.

The Annals of Otology, Rhinology, and Laryngology
|February 25, 1999
PubMed
Summary

Serum soluble CD23 (sCD23) levels are elevated in allergic rhinitis patients and decrease with immunotherapy, correlating with reduced specific IgE and symptoms. This suggests sCD23 plays a role in allergic disease expression and treatment efficacy.

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Area of Science:

  • Immunology
  • Allergology
  • Clinical Medicine

Background:

  • Soluble CD23 (sCD23) is implicated in human IgE synthesis and allergic disease pathogenesis.
  • In vitro studies suggest sCD23 potentiates IgE production, highlighting its potential role in allergic conditions.

Purpose of the Study:

  • To investigate serum sCD23 levels in perennial allergic rhinitis (PAR) patients compared to controls.
  • To determine if sCD23 levels fluctuate naturally in untreated PAR patients.
  • To assess the impact of immunotherapy on sCD23 levels in PAR patients.

Main Methods:

  • 139 PAR patients (Dermatophagoides farinae allergy) and 31 controls were enrolled.
  • Patients were divided into untreated and immunotherapy groups.
  • Serum sCD23 and specific IgE levels were measured using ELISA at baseline and follow-up.

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Main Results:

  • Serum sCD23 was significantly higher in PAR patients than controls (p < .0001).
  • sCD23 levels correlated with specific IgE against D. farinae.
  • sCD23 levels decreased significantly with immunotherapy (p < .0001) and correlated with symptom score reduction.

Conclusions:

  • Elevated serum sCD23 is characteristic of perennial allergic rhinitis.
  • Immunotherapy effectively reduces sCD23 levels, which is linked to decreased specific IgE and improved symptoms.
  • sCD23 reduction during immunotherapy may contribute to its clinical benefits in allergic rhinitis.